NMR Research Investigator position at Bristol-Myers Squibb
June 23, 2008

Dear Colleagues, Our group has an opening for an NMR spectroscopist. I seek your assistance in identifying a strong candidate with an interest in developing and applying state-of-the-art biological NMR methods to support drug discovery efforts at BMS. Research in the group covers a broad spectrum of topics, from the three-dimensional structure determination of protein-ligand complexes to hit identification and characterization to protein dynamics. I would greatly appreciate it if you would forward this note to any potential candidates, who should then apply for the position as indicated at the end of this e-mail. Thanks in advance. Bill Metzler Position: Research Investigator I/II Job Number: #25450 Department: Applied Biotechnology-NMR LIST RESPONSIBILITIES REQUIRED: Maintain broad knowledge and expertise in the principles and theories of NMR spectroscopy. Identify, implement and evaluate new technologies that can enhance NMR impact on drug discovery. Investigate and develop new methods to characterize the interaction of ligands with their target proteins. Maintain and troubleshoot NMR instrumentation. Achieve research objectives. Handle multiple projects in parallel. Closely collaborate with scientists within own department as well as with external customers. Communicate results and protocols at project meetings. Represent departmental function on program teams. LIST MAJOR SKILLS REQUIRED: A Ph.D. in BioPhysics, Chemistry, Biochemistry, or Structural Biology is preferred, but equivalent industrial experience can be substituted. Ph.D. with 2 or more years experience in NMR applied to biological applications. Demonstrated excellence of an in depth understanding of NMR theory Demonstrated experience in developing and implementing state of the art experiments for high resolution biological NMR applications. Demonstrated knowledge of NMR instrumentation and ability to perform routine trouble shooting. Demonstrated excellence in practical application of NMR to biological samples, including structure determination of protein ligand complexes by NMR, and characterization of ligand binding to proteins. Demonstrated ability to solve problems, with a strong interest in applying NMR to solve biological problems. Demonstrated ability to handle and manipulate biological samples. Excellent interpersonal and communication skills, along with a sense of urgency and ability to work under tight deadlines. Qualified candidates must have the ability to work as part of a team, be self motivated and work independently. Personal attributes of integrity and scientific creativity. Customer oriented attitude toward scientific colleagues. A strong interest in drug discovery is essential. ADDITIONAL SKILLS BENEFICIAL: Demonstrated experience in protein engineering, fermentation and or cell culture techniques. Demonstrated experience in protein purification. Demonstrated experience in physical characterization techniques for protein systems such as CD, calorimetry, BiaCore SPR, fluorescence spectroscopy, light scattering, and or analytical ultracentrifugation. A working knowledge of Enzyme Kinetics. Experience with automation and laboratory instrument data management. · Go online to http://www.bms.com/career/data/ and register to view current career openings and apply to Job Number #25450. · Register your resume and create a search agent for interest in future openings. · Please be aware that you must apply online via our web site to be officially considered an applicant to any Bristol-Myers Squibb job posting. Bristol-Myers Squibb Company is an Equal Opportunity Employer M/F/D/V